Phentermine Adipex 37.5mg

Buy Phentermine 37.5mg online in USA.Phentermine (phenyl–tertiary-butylamine), with several brand names including Ionamin and Sentis, is a medication used together with diet and exercise to treat obesity.^[3] It is taken by mouth for up to a few weeks at a time, after which the benefits subside.^[3] It is also available as the combination phentermine/topiramate.^[5]

Common side effects include a fast heart beat, high blood pressure, trouble sleeping, dizziness, and restlessness.^[3] Serious side effects may include abuse, but do not include pulmonary hypertension or valvular heart disease, as the latter were caused by the fenfluramine component of the fen-phen drug combination.^[3] Use is not recommended during pregnancy or breastfeeding,^[6] or with SSRIs or MAO inhibitors.^[3] It works mainly as an appetite suppressant, likely as a result of being a CNS stimulant.^[3] Chemically, phentermine is a substituted amphetamine.^[7]

Phentermine was approved for medical use in the United States in 1959.^[3] It is available as a generic medication.^[3] In 2020, it was the 181st most commonly prescribed medication in the United States, with more than 3 million prescriptions.^[8][9] Phentermine was withdrawn from the market in the United Kingdom in 2000, while the combination medication fen-phen, of which it was a part, was withdrawn from the market in 1997 due to side effects^[10] of fenfluramine which caused increased levels of circulating serotonin which stimulated serotonin receptors on heart valves and thus causing valve insufficiency and leading to primary pulmonary hypertension (PPH). According to the NIH (National Institutes of Health) there is no evidence that phentermine causes PPH.^[c

Medical uses

Phentermine is used for a short period of time to promote weight loss, if exercise and calorie reduction are not sufficient, and in addition to exercise and calorie reduction.^[4][11]

Phentermine is approved for up to 12 weeks of use and most weight loss occurs in the first weeks.^[11] However, significant loss continues through the sixth month and has been shown to continue at a slower rate through the ninth month.^[12]

Contraindications

Phentermine is contraindicated for users who:^[4][11]

• have a history of drug abuse
• are allergic to sympathomimetic amine drugs
• are taking a monoamine oxidase inhibitor (MAOI) or have taken one within the last 14 days
• have cardiovascular disease, hyperthyroidism, or glaucoma
• are pregnant, planning to become pregnant, or breast-feeding.

Adverse effects

Tolerance usually occurs; however, risks of dependence and addiction are considered negligible.^[12][13] People taking phentermine may be impaired when driving or operating machinery.^[11] Consumption of alcohol with phentermine may produce adverse effects.^[11]

There is currently no evidence regarding whether or not phentermine is safe for pregnant women.^[4][11]

Other adverse effects include:^[4][11]

• Cardiovascular effects like palpitations, tachycardia, high blood pressure, precordial pain; rare cases of stroke, angina, myocardial infarction, cardiac failure and cardiac arrest have been reported.
• Central nervous system effects like overstimulation, restlessness, nervousness, insomnia, tremor, dizziness and headache; there are rare reports of euphoria followed by fatigue and depression, and very rarely, psychotic episodes and hallucinations.
• Gastrointestinal effects include nausea, vomiting, dry mouth, cramps, unpleasant taste, diarrhea, and constipation.
• Other adverse effects include trouble urinating, rash, impotence, changes in libido, and facial swelling.

Interactions

Phentermine may decrease the effect of drugs like clonidine, methyldopa, and guanethidine. Drugs to treat hypothyroidism may increase the effect of phentermine.^[11]

Mechanism of action

Phentermine has some similarity in its pharmacodynamics with its parent compound, amphetamine, as they both are TAAR1 agonists,^[14] where the activation of TAAR1 in monoamine neurons facilitates the efflux, or release into the synapse, of these neurochemicals. At clinically relevant doses, phentermine primarily acts as a releasing agent of norepinephrine in neurons, although, to a lesser extent, it releases dopamine and serotonin into synapses as well.^[13][15] Phentermine may also trigger the release of monoamines from VMAT2, which is a common pharmacodynamic effect among substituted amphetamines. The primary mechanism of phentermine’s action in treating obesity is the reduction of hunger perception, which is a cognitive process mediated primarily through several nuclei within the hypothalamus (in particular, the lateral hypothalamic nucleus, arcuate nucleus, and ventromedial nucleus). Outside the brain, phentermine releases norepinephrine and epinephrine – also known as noradrenaline and adrenaline respectively – causing fat cells to break down stored fat as well.